Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society

The goal of this current guideline is to provide evidence-based answers to efficacy, safety, and tolerability questions regarding the treatment of convulsive status epilepticus and to synthesize these answers into a treatment algorithm. This guideline focuses on convulsive status epilepticus because it is both the most common type of status epilepticus and is associated with substantial morbidity and mortality.

Individual studies were rated using predefined criteria and these results were used to form recommendations, conclusions, and an evidence-based treatment algorithm. : A total of 38 randomized controlled trials were identified, rated and contributed to the assessment. Only four trials were considered to have class I evidence of efficacy. Two studies were rated as class II and the remaining 32 were judged to have class III evidence.