Alzheimer's disease

Alzheimer disease (AD) is a common neurodegenerative disease, responsible for 60-80% of all dementias, and imposing a significant burden on developed nations. It is the result of accumulation and deposition of cerebral amyloid-β (Aβ) and is the most common cerebral amyloid deposition disease. 
Epidemiological risk factors have been identified:
-advanced age
-female gender
-apolipoprotein E (APOE) ε4 allele carrier status
-current smoking
-family history of dementia
-mutations of amyloid precursor protein
-Down syndrome