• Cancer
    • Colorectal Cancer
    • Lymphoma
    • Penile Cancer
    • Uterine Cancer
    • Breast Cancer
    • Stomach Cancer
    • Bone Cancer
    • Cervical Cancer
    • Brain Cancer
    • Leukemia (Blood Cells Cancer)
    • Endometrial Cancer
    • Neuroblastoma
    • Kidney Cancer
  • Brain
    • Stroke
    • Dyslexia
    • Down Syndrome
    • Cerebral Palsy
    • Attention Deficit Hyperactivity Disorder (ADHD)
    • Alcoholism
    • Autism
    • Multiple Sclerosis
    • Epilepsy
    • Schizophrenia
    • Insomnia
    • Alzheimer’s Disease
    • Parkinson’s Disease
    • Migraine
    • Phobia
  • Heart
    • Hypertension
    • Endocarditis
    • Coronary Heart Disease
    • Myocardial Infarction (Heart Attack)
    • Arrhythmia
    • Angina
    • Enlarged heart
    • Pericarditis
    • Venous Thromboembolism (VTE)
    • Peripheral Arterial Disease
    • Ventricular Septal Defect
    • Hypotension (Low Blood Pressure)
  • Kidney & URO
    • Chronic Kidney Disease
    • Diabetic Nephropathy
    • Urinary Tract Infection
    • Prostatitis
    • Urinary Incontinence
    • Enlarged Prostate
    • Blood in Urine (Hematuria)
    • Kidney Stones
    • Erectile Dysfunction
    • Cystitis
  • Eye
    • Myopia
    • Glaucoma
    • Dry Eyes
    • Conjunctivitis
    • Cataracts
    • Color Blindness
    • Macular Degeneration
    • Diabetic Retinopathy
    • Retinal Detachment
    • Keratoconus
  • Skin
    • Shingles
    • Rosacea
    • Eczema
    • Vitiligo
    • Psoriasis
    • Scabies
    • Acne
    • Dandruff
  • OBS/GYN
    • Uterine Fibroids
    • Polycystic Ovary Syndrome (PCOS)
    • Vaginitis
    • Endometriosis
    • Preeclampsia
    • Menstruation (Period)
    • Ovarian Cyst
    • Pelvic Inflammatory Disease
  • GI Tract
    • Celiac Disease
    • Hemorrhoids
    • Achalasia
    • Diarrhea
    • Gastroesophageal Reflux Disease (GRED)
    • Diverticulitis
    • Liver Cirrhosis
    • Irritable Bowel Syndrome
    • Constipation
    • Appendicitis
    • Ulcerative Colitis
    • Gallstones
    • Crohn’s Disease
  • Bones & Joints
    • Osteoarthritis
    • Osteoporosis
    • Bone Cyst
    • Osteomyelitis (Bone Infection)
    • Sciatica
    • Fibromyalgia
    • Calcium Deficiency (Hypocalcemia)
    • Gout
    • Rickets in Children
    • Spinal Stenosis
  • Dental
    • Periodontal Disease
    • Dental Caries
    • Bad Breath
    • Sensitive Teeth
    • Dry Mouth
    • Supernumerary Teeth
    • Bruxism (Teeth Grinding)
    • Tooth Loss (Edentulism)
    • Impacted Tooth (Tooth Impaction)
  • Others
    • Hyperthyroidism
    • Rhinitis
    • Chronic Obstructive Pulmonary Disease (COPD)
    • Thalassemia
    • Hepatitis
    • Sinusitis
    • Acromegaly
    • Health and Wellness
    • Achondroplasia
    • Diabetes Mellitus
    • Asthma
    • Coronavirus Disease (Covid-19)
    • Sleep Apnea
    • Tuberculosis

Write For Us

What's Hot

Physical and Psychological Symptoms of Bulimia

January 28, 2023

The Impact of Gonorrhea on Reproductive and Overall Health

January 28, 2023

The Role of Diet and Exercise in Managing Ankylosing Spondylitis and Tips for Maintaining a Healthy Lifestyle

January 27, 2023
Facebook Twitter YouTube
DiseaseFix – World's Largest Disease Information Center
  • Write For Us
Facebook Twitter YouTube
  • Cancer
    • Colorectal Cancer
    • Lymphoma
    • Penile Cancer
    • Uterine Cancer
    • Breast Cancer
    • Stomach Cancer
    • Bone Cancer
    • Cervical Cancer
    • Brain Cancer
    • Leukemia (Blood Cells Cancer)
    • Endometrial Cancer
    • Neuroblastoma
    • Kidney Cancer
  • Brain
    • Stroke
    • Dyslexia
    • Down Syndrome
    • Cerebral Palsy
    • Attention Deficit Hyperactivity Disorder (ADHD)
    • Alcoholism
    • Autism
    • Multiple Sclerosis
    • Epilepsy
    • Schizophrenia
    • Insomnia
    • Alzheimer’s Disease
    • Parkinson’s Disease
    • Migraine
    • Phobia
  • Heart
    • Hypertension
    • Endocarditis
    • Coronary Heart Disease
    • Myocardial Infarction (Heart Attack)
    • Arrhythmia
    • Angina
    • Enlarged heart
    • Pericarditis
    • Venous Thromboembolism (VTE)
    • Peripheral Arterial Disease
    • Ventricular Septal Defect
    • Hypotension (Low Blood Pressure)
  • Kidney & URO
    • Chronic Kidney Disease
    • Diabetic Nephropathy
    • Urinary Tract Infection
    • Prostatitis
    • Urinary Incontinence
    • Enlarged Prostate
    • Blood in Urine (Hematuria)
    • Kidney Stones
    • Erectile Dysfunction
    • Cystitis
  • Eye
    • Myopia
    • Glaucoma
    • Dry Eyes
    • Conjunctivitis
    • Cataracts
    • Color Blindness
    • Macular Degeneration
    • Diabetic Retinopathy
    • Retinal Detachment
    • Keratoconus
  • Skin
    • Shingles
    • Rosacea
    • Eczema
    • Vitiligo
    • Psoriasis
    • Scabies
    • Acne
    • Dandruff
  • OBS/GYN
    • Uterine Fibroids
    • Polycystic Ovary Syndrome (PCOS)
    • Vaginitis
    • Endometriosis
    • Preeclampsia
    • Menstruation (Period)
    • Ovarian Cyst
    • Pelvic Inflammatory Disease
  • GI Tract
    • Celiac Disease
    • Hemorrhoids
    • Achalasia
    • Diarrhea
    • Gastroesophageal Reflux Disease (GRED)
    • Diverticulitis
    • Liver Cirrhosis
    • Irritable Bowel Syndrome
    • Constipation
    • Appendicitis
    • Ulcerative Colitis
    • Gallstones
    • Crohn’s Disease
  • Bones & Joints
    • Osteoarthritis
    • Osteoporosis
    • Bone Cyst
    • Osteomyelitis (Bone Infection)
    • Sciatica
    • Fibromyalgia
    • Calcium Deficiency (Hypocalcemia)
    • Gout
    • Rickets in Children
    • Spinal Stenosis
  • Dental
    • Periodontal Disease
    • Dental Caries
    • Bad Breath
    • Sensitive Teeth
    • Dry Mouth
    • Supernumerary Teeth
    • Bruxism (Teeth Grinding)
    • Tooth Loss (Edentulism)
    • Impacted Tooth (Tooth Impaction)
  • Others
    • Hyperthyroidism
    • Rhinitis
    • Chronic Obstructive Pulmonary Disease (COPD)
    • Thalassemia
    • Hepatitis
    • Sinusitis
    • Acromegaly
    • Health and Wellness
    • Achondroplasia
    • Diabetes Mellitus
    • Asthma
    • Coronavirus Disease (Covid-19)
    • Sleep Apnea
    • Tuberculosis
DiseaseFix – World's Largest Disease Information Center
Home » Diseases and Conditions » Castleman's Disease » Know About Castleman’s Disease

Know About Castleman’s Disease

Amina Ahmad, MS, BiotechnologyBy Amina Ahmad, MS, Biotechnology5 Mins Read
Facebook Twitter Pinterest LinkedIn Tumblr Email
Share
Facebook Twitter LinkedIn Pinterest Email
Contents Hide
1 What is Castleman’s Disease?
2 Types of Castleman disease
3 Signs and symptoms of Castleman’s disease
4 Diagnosis of Castleman’s Syndrome
5 Treatment of Castleman’s disease

What is Castleman’s Disease?

Castleman’s disease is a rare disorder of lymph nodes and surrounding tissues characterized by an overgrowth of cells of the lymph nodes. Even though it is not a cancer, but it appears like a cancer of lymph organs (lymphoma).

Castleman’s disease is named after Dr. Benjamin Castleman who described it, in 1950s. An estimate suggests that approximately 4500 to 7,700 new cases of Castleman’s syndrome are observed per year in the United States.

Types of Castleman disease

Depending upon how a body is affected by the disease and the prevalent symptoms, Castleman’s disease is divided into two subtypes:

Localized Castleman’s disease

Another name for localized Castleman’s disease is unicentric Castleman’s disease. This condition is more commonly found compared to the other one and affects only a single group of lymph nodes. Localized Castleman’s disease commonly affects the chest or abdomen or belly.

Multicentric Castleman’s disease

Multicentric Castleman’s disease (MCD) affects multiple regions of enlarged lymph nodes. These lymph nodes are more commonly located in areas such as the neck, collarbone, underarm, and groin areas. It is a widespread condition and is known to weaken the body’s immune system which makes it hard to fight infections. Some viral infections are also associated with this condition.

Other uncommon types of Castleman’s disease are hyaline vascular type, plasma cell type, mixed, plasmablastic, etc.

Signs and symptoms of Castleman’s disease

People suffering from localized Castleman’s disease experience symptoms such as:

  • enlargement of nodes in the chest (which may create a pressure on the windpipe) is a common sign of Castleman’s disease
  • fever
  • unintended or frequent weight loss
  • fatigue and nausea
  • night sweats
  • skin rash
  • hemolytic anemia or low level of circulating red blood cells
  • enlargement of spleen or liver
  • feeling of fullness in the chest
Causes and Genetics of Castleman Disease

Similar symptoms are observed in multicentric Castleman’s disease. Symptoms of multicentric CD are more commonly observed in men than in women. Multicentric CD causes the liver, spleen, or other organs to enlarge which can be felt as masses under either side of the rib cage. Multicentric Castleman’s disease sometimes causes pain in the abdomen.

Sometimes, amyloidosis, or anemia is also associated with Castleman’s disease. These symptoms might also be related to any other disease, therefore a proper diagnosis is necessary for detecting the Castleman’s disease.

Diagnosis of Castleman’s Syndrome

Castleman’s Disease is a rare condition and its symptoms are similar to several autoimmune diseases, lymphomas, etc. Therefore, doctors often suspect it to be something else in the beginning.

During physical examination of a patient by a doctor, the size and shape of the lymph nodes are examined and the medical history of the patient is studied. Common tests to diagnose Castleman’s Disease are:

Imaging scans

Imaging scans are recommended to confirm the diagnosis if the doctor suspects Castleman’s Disease in a physical examination. A CT scan is helpful in taking detailed images of inside the body. MRI scan uses radio waves to get pictures of lymph nodes. An ultrasound uses sound waves to get images of the organs.

Imaging tests are helpful in diagnosing enlarged lymph nodes in any part of the body. Diagnosis of the disease through image scanning can also help in understanding if a particular treatment method is effective. A chest x-ray is also initially recommended if a person is suffering from breathing difficulty.

Blood and urine tests

Blood and urine analysis helps to rule out the possibility of other related infections or diseases. Several tests involving complete blood count (CBC), Interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), kidney function, etc may be recommended by the doctor. Blood tests are recommended if inflammation is observed in the body.

Biopsy for the diagnosis of Castleman’s Disease

A small piece of an enlarged lymph node is viewed under a microscope to detect an abnormality. Fine needle biopsy is recommended in most cases. Biopsy is mainly done to differentiate Castleman’s disease from other types of lymphatic tissue disorders such as the cancer. Lab tests which are used to study biopsy samples include such as polymerase chain reaction (PCR), cytogenetics, immunohistochemistry, flow cytometry, fluorescent in situ hybridization (FISH), etc.

Treatment of Castleman’s disease

The treatment for Castleman’s disease depends on the type of disease:

Treatment of Unicentric Castleman Disease

Localized Castleman’s disease is treated by removing the diseased lymph node with the help of surgery. If the lymph nodes are too large, they are first treated with radiation therapy followed by a surgery. These lymph nodes have rare chances to relapse. More about treating Castleman’s Disease.

Treatment of Multicentric Castleman’s Disease

Multicentric Castleman disease is treated through medications and other therapies that help in controlling cell overgrowth. It is observed that long-term outlook for MCD is not as good as in case of unicentric Castleman’s disease because there is no standard therapy to treat this condition. Also, it is observed that no single treatment works the same way for each patient.

Amina Ahmad, MS, Biotechnology
  • LinkedIn

Amina Ahmad is a bio-technologist and aims to deliver a positive contribution in healthcare industry by spreading health awareness in general public. She completed Masters in Technology (Biotechnology) from IMS Engineering College (AKTU). Then, she moved to Jamia Millia Islamia, a technological University in New Delhi, where she worked in the Research Division of Life Sciences Department as a researcher. She was also associated with Advancells, a stem cell company, as a Research Associate and laboratory expert in the past. Currently, Amina is associated with DiseaseFix as a Research Associate and medical content writer. With DiseaseFix, she aspires to educate people about problems associated with their health by helping them understand the disease basics and available treatment options in this new technologically advanced age of the medical arena. Her expertise includes nano-biotechnology, antibacterial benefits of plants, and neglected diseases.

Related Posts

Preparing For Your Appointment With A Doctor For Castleman’s Disease

October 3, 2019

Castleman’s Disease: Emerging Treatments

September 20, 2019

Castleman’s Disease: Cause and Genetics

February 12, 2019

Leave A Reply Cancel Reply

Don't Miss
Bulimia Nervosa

Physical and Psychological Symptoms of Bulimia

By Vishakha Yadav3 Mins Read

Bulimia is characterized by repetitive episodes of binge eating followed by compensatory behaviors such as purging, excessive exercise, or fasting. Physical symptoms may include weight fluctuations, gastrointestinal problems, dental problems, and electrolyte imbalances. Psychological symptoms may include low self-esteem, anxiety, depression, and distorted body image.

The Impact of Gonorrhea on Reproductive and Overall Health

January 28, 2023

The Role of Diet and Exercise in Managing Ankylosing Spondylitis and Tips for Maintaining a Healthy Lifestyle

January 27, 2023

Treatment Options for Gonorrhea

January 27, 2023
Latest Posts

Physical and Psychological Symptoms of Bulimia

January 28, 2023

The Impact of Gonorrhea on Reproductive and Overall Health

January 28, 2023

The Role of Diet and Exercise in Managing Ankylosing Spondylitis and Tips for Maintaining a Healthy Lifestyle

January 27, 2023

Treatment Options for Gonorrhea

January 27, 2023

Why Is My Pee Burning? 5 Reasons Urination Can Be Painful

January 25, 2023
About Us
About Us

DiseaseFix is primarily known as an online publisher of disease-centric medical information related to human health and well-being. The information is published as disease modules accessible to users from across the world free of cost.

Email Us: contact@diseasefix.com

Our Picks

Moving Forward After Breast Cancer Surgery

December 30, 2022

Five Things Patients Experience Immediately After Breast Cancer Diagnosis

April 23, 2021

Real Life Experiences About Coping With Cancer

April 22, 2021
Company

Disease Index

About Us

Our Team

Privacy Policy

Disclaimer

Contact Us

Write For Us

 

Facebook Twitter YouTube
© 2023 Diseasefix. All rights reserved.

Type above and press Enter to search. Press Esc to cancel.