Thalassemia is a hereditary blood disorder characterized by less hemoglobin and a smaller number of red blood cells in the body than normal. Hemoglobin is a substance in our red blood cells that helps in the transport of oxygen in our body.
Cooley’s anemia is often associated with severe anemia which causes symptoms like fatigue, weakness, shortness of breath, dizziness, headaches, and yellowing of the skin, mucous membranes and jaundice. Affected infants often fail to thrive and are unable to grow and gain weight as expected.
People who have thalassemia trait (also called thalassemia minor) carry the genetic trait for thalassemia but do not suffer from any health problems except a mild anemia. A person may have either alpha thalassemia trait or beta thalassemia trait, depending upon which form of beta protein is absent.
Alpha thalassemia occurs when there is a mutation in the gene that codes for alpha globin which therefore results in reduced or absent production of alpha globins. Beta thalassemia occurs with a related change in the beta globin gene.
Alpha thalassemia is a blood disorder that decreases the production of normal hemoglobin. Beta thalassemia occurs due to less or no synthesis of beta globin chains, resulting in increased number of alpha chains.