What is Chronic Kidney Disease?

Tatheer Zehra Zaidi   by Tatheer Zehra Zaidi, M. Pharma    Last updated on February 21, 2021,

what is chronic kidney disease?


Overview of Chronic Kidney Disease (CKD)

Chronic kidney disease, also called chronic kidney failure, is defined as the gradual loss of kidney function. Our kidneys filter waste matter and excess fluids from the blood, which are then excreted in the urine. In case of chronic kidney disease, the levels of fluids, electrolytes and waste matters build up in the body. In the initial stages, you may notice no or few signs or symptoms. The disease may not become visible until the kidney function is significantly disturbed. It is diagnosed by blood test and has no physical indications/ symptoms. Longstanding sickness of the kidneys prompts renal failure.

Constant kidney illness, likewise called chronic kidney failure, depicts the slow loss of kidney work. Your kidneys channel squanders and overabundance liquids from your blood, which are then discharged in your urine. At the point when interminable kidney illness achieves a propelled stage, risky levels of liquid, electrolytes and squanders can develop in your body. 

CKD can be broadly defined as the presence of:

  • Kidney impairment- Pathological abnormalities
  • Glomerular Filteration Rate (GFR)- <60 ml/ min for 3 months or longer

In the early phases of interminable kidney ailment, you may have few signs or side effects. Unending kidney infection may not wind up plainly clear until the point when your kidney work is altogether debilitated.

Treatment for constant kidney illness concentrates on moderating the movement of the kidney harm, more often than not by controlling the basic reason. Constant kidney illness can advance to end-arrange kidney disappointment, which is lethal without dialysis or a kidney transplant.

CKD can be recorded as stages in light of the patient's level of glomerular filtration rate (GFR) which is a measure of filtering limit of the kidneys. Stage 1 implies ordinary filtering capacity of the kidney yet outlines those patients that are at danger of dynamic renal sickness, for example, those with proteinuria or hematuria. Stage 2 is utilized for patients with a GFR of 60 to 90 mL for every moment. Stage 3 is utilized for patients with a glomerular filtration rate of 30 to 60 mL for every moment. Stage 4 is for patients with a glomerular filtration rate of 15 to 30 mL for every moment. Stage 5 is for patients with a glomerular filtration rate of under 15 mL for each moment, however who are not on dialysis. Stage 6 is for patients who have a glomerular filtration rate of under 15 mL for each moment and require dialysis mediation for their renal disappointment. 

Interminable kidney disappointment or constant renal disappointment means loss of kidney work that happens over a delayed course of time instead of intense renal disappointment. The loss of renal capacity might be because of past scenes of intense renal disappointment with resulting long haul kidney harm or might be because of infections which cause dynamic decay of the kidney, for example, essential kidney illness (glomerulonephritis) or auxiliary issue, for example, diabetes, hypertension, or auto-resistant clutters. The loss of kidney capacity might be dynamic, however, with treatment of the fundamental reason, the harm can be ended and sometimes the kidney capacity may really move forward. Sadly, numerous patients with ceaseless kidney infection, particularly on the off chance that they achieve Stage 4 or Stage 5 will advance to purpose of end stage renal disease (ESRD) which is the purpose of requiring dialysis or renal transplant. In the event the patient has begun on dialysis, this is synonymous with endless kidney illness Stage 6. Patients with analyzed CKD will probably bite the dust from cardiovascular disease (CVD) than advance to end stage renal malady, so intercessions to limit cardiovascular hazard are essential.

Facts about Chronic Kidney Disease

  •   The risk of CKD increases for people older than 65 years in age.
  •   The condition can run in families. 
  •   It’s more likely to develop in African-Americans, Native Americans, and Asian-Americans. 
  •   10% of the world population is affected by chronic kidney disease, and several millions of people die each year because they do not have access to affordable and timely treatment.
  •   About 2 million people worldwide receive treatment with dialysis or a kidney transplant to continue their lives. And this number only represents 10% of the people who need the treatment to live.
  •   Chronic kidney disease is a health crisis throughout the world. In the year 2005, there were about 58 million deaths worldwide. 35 million of them were attributed to chronic disease, according to data from the World Health Organization.
  •   The disease can be treated. The progression can be slowed down or stopped with early diagnosis and treatment.

Tatheer Zehra Zaidi

Tatheer Zehra Zaidi is a clinical pharmacist and pharmacologist with a master’s degree in pharmacy practice. She aims to deliver a positive contribution in the field of healthcare and research. She received her bachelor’s and master’s degrees from Jamia Hamdard New Delhi and then joined Spirant Communication Private LTD as a Medical content writer.


Currently she is working at Maxinov Solutions Private LTD as a research associate and is associated with DiseaseFix as a medical content writer. Tatheer’s areas of interest include clinical research, clinical trial disclosure, and pharmacovigilance.

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