Close Menu
  • Cancers
    • Colorectal Cancer
    • Lymphoma
    • Penile Cancer
    • Uterine Cancer
    • Breast Cancer
    • Stomach Cancer
    • Bone Cancer
    • Cervical Cancer
    • Brain Cancer
    • Leukemia (Blood Cells Cancer)
    • Endometrial Cancer
    • Neuroblastoma
    • Kidney Cancer
  • Brain
    • Stroke
    • Dyslexia
    • Down Syndrome
    • Cerebral Palsy
    • Attention Deficit Hyperactivity Disorder (ADHD)
    • Alcoholism
    • Autism
    • Multiple Sclerosis
    • Epilepsy
    • Schizophrenia
    • Insomnia
    • Alzheimer’s Disease
    • Parkinson’s Disease
    • Migraine
    • Phobia
  • Heart
    • Hypertension
    • Endocarditis
    • Coronary Heart Disease
    • Myocardial Infarction
    • Arrhythmia
    • Angina
    • Enlarged heart
    • Pericarditis
    • Venous Thromboembolism (VTE)
    • Peripheral Arterial Disease
    • Ventricular Septal Defect
    • Hypotension
  • Urinary Health
    • Chronic Kidney Disease
    • Diabetic Nephropathy
    • Urinary Tract Infection
    • Prostatitis
    • Urinary Incontinence
    • Enlarged Prostate
    • Blood in Urine
    • Kidney Stones
    • Erectile Dysfunction
    • Cystitis
  • Eye
    • Myopia
    • Glaucoma
    • Dry Eyes
    • Conjunctivitis
    • Cataracts
    • Color Blindness
    • Macular Degeneration
    • Diabetic Retinopathy
    • Retinal Detachment
    • Keratoconus
  • Skin
    • Shingles
    • Rosacea
    • Eczema
    • Vitiligo
    • Psoriasis
    • Scabies
    • Acne
    • Dandruff
  • Women Health
    • Uterine Fibroids
    • Pregnancy
    • Polycystic Ovary Syndrome
    • Vaginitis
    • Endometriosis
    • Preeclampsia
    • Menstruation
    • Ovarian Cyst
    • Pelvic Inflammatory Disease
  • Digestive Health
    • Celiac Disease
    • Hemorrhoids
    • Achalasia
    • Diarrhea
    • Gastroesophageal Reflux Disease
    • Diverticulitis
    • Liver Cirrhosis
    • Irritable Bowel Syndrome
    • Constipation
    • Appendicitis
    • Ulcerative Colitis
    • Gallstones
    • Crohn’s Disease
  • Bone Health
    • Osteoarthritis
    • Osteoporosis
    • Cyst
    • Osteomyelitis
    • Sciatica
    • Fibromyalgia
    • Calcium Deficiency
    • Gout
    • Rickets in Children
    • Spinal Stenosis
  • Dental
    • Periodontal Disease
    • Dental Caries
    • Bad Breath
    • Sensitive Teeth
    • Dry Mouth
    • Supernumerary Teeth
    • Bruxism
    • Tooth Loss
    • Impacted Tooth
  • More
    • Hyperthyroidism
    • Rhinitis
    • Chronic Obstructive Pulmonary Disease (COPD)
    • Thalassemia
    • Hepatitis
    • Sinusitis
    • Acromegaly
    • Health and Wellness
    • Achondroplasia
    • Diabetes Mellitus
    • Asthma
    • Coronavirus Disease (Covid-19)
    • Sleep Apnea
    • Tuberculosis

Write For Us

What's Hot

How Big Are Kidney Stones? Size Chart

February 3, 2021

What Do Words Look Like to a Dyslexic Person?

February 3, 2021
Gallstones without a gallbladder image

Can you Get Gallstones without a Gallbladder?

July 12, 2022
Facebook X (Twitter) YouTube
DiseaseFix – World's Largest Disease Information Center
  • Write For Us
  • Marketing Opportunities
Facebook X (Twitter) YouTube
  • Cancers
    • Colorectal Cancer
    • Lymphoma
    • Penile Cancer
    • Uterine Cancer
    • Breast Cancer
    • Stomach Cancer
    • Bone Cancer
    • Cervical Cancer
    • Brain Cancer
    • Leukemia (Blood Cells Cancer)
    • Endometrial Cancer
    • Neuroblastoma
    • Kidney Cancer
  • Brain
    • Stroke
    • Dyslexia
    • Down Syndrome
    • Cerebral Palsy
    • Attention Deficit Hyperactivity Disorder (ADHD)
    • Alcoholism
    • Autism
    • Multiple Sclerosis
    • Epilepsy
    • Schizophrenia
    • Insomnia
    • Alzheimer’s Disease
    • Parkinson’s Disease
    • Migraine
    • Phobia
  • Heart
    • Hypertension
    • Endocarditis
    • Coronary Heart Disease
    • Myocardial Infarction
    • Arrhythmia
    • Angina
    • Enlarged heart
    • Pericarditis
    • Venous Thromboembolism (VTE)
    • Peripheral Arterial Disease
    • Ventricular Septal Defect
    • Hypotension
  • Urinary Health
    • Chronic Kidney Disease
    • Diabetic Nephropathy
    • Urinary Tract Infection
    • Prostatitis
    • Urinary Incontinence
    • Enlarged Prostate
    • Blood in Urine
    • Kidney Stones
    • Erectile Dysfunction
    • Cystitis
  • Eye
    • Myopia
    • Glaucoma
    • Dry Eyes
    • Conjunctivitis
    • Cataracts
    • Color Blindness
    • Macular Degeneration
    • Diabetic Retinopathy
    • Retinal Detachment
    • Keratoconus
  • Skin
    • Shingles
    • Rosacea
    • Eczema
    • Vitiligo
    • Psoriasis
    • Scabies
    • Acne
    • Dandruff
  • Women Health
    • Uterine Fibroids
    • Pregnancy
    • Polycystic Ovary Syndrome
    • Vaginitis
    • Endometriosis
    • Preeclampsia
    • Menstruation
    • Ovarian Cyst
    • Pelvic Inflammatory Disease
  • Digestive Health
    • Celiac Disease
    • Hemorrhoids
    • Achalasia
    • Diarrhea
    • Gastroesophageal Reflux Disease
    • Diverticulitis
    • Liver Cirrhosis
    • Irritable Bowel Syndrome
    • Constipation
    • Appendicitis
    • Ulcerative Colitis
    • Gallstones
    • Crohn’s Disease
  • Bone Health
    • Osteoarthritis
    • Osteoporosis
    • Cyst
    • Osteomyelitis
    • Sciatica
    • Fibromyalgia
    • Calcium Deficiency
    • Gout
    • Rickets in Children
    • Spinal Stenosis
  • Dental
    • Periodontal Disease
    • Dental Caries
    • Bad Breath
    • Sensitive Teeth
    • Dry Mouth
    • Supernumerary Teeth
    • Bruxism
    • Tooth Loss
    • Impacted Tooth
  • More
    • Hyperthyroidism
    • Rhinitis
    • Chronic Obstructive Pulmonary Disease (COPD)
    • Thalassemia
    • Hepatitis
    • Sinusitis
    • Acromegaly
    • Health and Wellness
    • Achondroplasia
    • Diabetes Mellitus
    • Asthma
    • Coronavirus Disease (Covid-19)
    • Sleep Apnea
    • Tuberculosis
DiseaseFix – World's Largest Disease Information Center
Home » Brain and Neurological Conditions » Autism » Brain Imaging of Rodents Reveals Interesting Insights Into Autism

Brain Imaging of Rodents Reveals Interesting Insights Into Autism

Mohd SadiqBy Mohd Sadiq3 Mins Read
Facebook Twitter Pinterest LinkedIn Tumblr Email
Share
Facebook Twitter LinkedIn Pinterest Email

Rodent models of ASDs (Autism spectrum disorders) coupled to new budding technologies for genome editing, cell-specific functional and structural imaging, and neuronal activity manipulation will yield critical insights about autism and stimulate the emergence of new treatments.

Autism is a neurological and developmental disorder that usually begins early in childhood and may last throughout a person’s life. It affects social interaction, developmental language, communication skills, and learning capability. Read about symptoms of autism in children.

We know that humans and mice brain circuits are evolutionarily conserved. So, researchers are trying to map brain connectivity in mice that have dissimilar mutations linked to autism. By mapping the effects of a suitably large number of mutations, alterations in the brain circuitry is being acknowledged. Finally, these rodents would be useful in future for reviewing the interconnection of a specific environmental stimulus.

Recommended:

Siblings of Autistic Children May Also Face Trouble

Understanding an Autism Diagnosis Test

Researchers used functional magnetic resonance imaging (fMRI) to create maps of brain activity in a mice, which was asleep. Contemporaneous activity in brain regions is found to be connected in a circuit. By comparative analysis between control and mutant mice, brain imaging may depict autism mutations affecting common brain circuits. Researchers investigated whether these alterations are present in humans with autism who have the same mutation. The brain imaging associated with mutations in rodents has also been thoroughly investigated, enabling to relate abnormal brain functioning to definite changes in brain neural function.

Similar circuit alterations in mice showed reduced communication could explain the autism-like behaviors observed in these rodents. These similarities suggest that the circuit alterations in people with autism involve physiological impairments that researchers can model in mice and map using fMRI.

Autism is clinically heterogeneous and often referred to as spectrum disorders as there is a wide variation in the severity of its symptoms, including, cerebral abnormalities, hyperactivity, sensory processing disability, and seizures. The analysis of autism is composite and has been attributed to genetic factors. However, the identification of causative genetic changes is only the first essential step for understanding how each genetic change alters downstream molecular cascades, perturbs brain development and function and ultimately leads to autism-related behaviors.

Rodent models incorporating this growing list of genetic changes are one of the prime methods used to dissect the effects of gene mutations on neuronal anatomy, connectivity, physiology, and behavior. Researchers using mouse models of autism discuss ways these rodent models could be used to study ASD pathogenesis and find new treatments

Why use mouse models to understand the insight into autism

Mouse model systems have been used to provide insights into the investigation of various diseases and have been helpful in the discovery of pharmacologic therapies for human illness. Mice and humans share a great similarity of genes due to their close evolutionary relationship. Various biological processes and brain circuitries of humans and mice share this similarity. Although autism is uniquely human disorder, however, behavioral investigation through parallel analysis among human and mice can determine core deficits using experimental manipulations through genetic engineering and other cutting-edge technologies. It may provide relevant information to understand the underlying mechanism of the disorder and may also lead to the development of targeted and effective therapeutic approaches that can be helpful to save human life.

Mohd Sadiq
  • LinkedIn

Mohd Sadiq is a bioinformaticist with a special interest in Nanotechnology. He completed his Master’s degree from Jamia Millia Islamia University, New Delhi, followed by an internship in the Department of Plant Molecular Biology, University of Delhi, South Campus. Mohd Sadiq has also worked at Codon Biotech Pvt. Ltd. Noida.

Follow-Up Reads

Siblings of Autistic Children May Also Face Trouble

April 23, 2021

Signs and Symptoms of Autism in Different Age Groups

April 23, 2021

What are the Various Treatment Options for Autism?

April 23, 2021

Leave A Reply Cancel Reply

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Best Practices for staying Healthy: Strategies & Tactics
doctor with mask Health and Wellness

Treatment for COPD in the Elderly Explained

By Kapil Sharma5 Mins Read

Chronic obstructive pulmonary disease (COPD) is a common and debilitating condition that affects the lungs,…

Lemon Juice Glass

Top 10 Home Remedies to Pass a Kidney Stone in 24 Hours

February 20, 2023
Runny Nose

Spike in H3N2 Influenza Cases in Delhi-NCR

February 16, 2023
Newborn child

Healing From a Stillbirth or Infant Loss: A Guide for Parents

February 14, 2023
Latest Posts
Sauna Therapy for Sleep

Sauna Therapy for Improved Sleep Quality

December 7, 2023
H30 water in fruits

The Health Benefits of Staying Hydrated With H30 Water in Fruits

December 7, 2023
Kidney Stones Composition

The Science Behind Kidney Stones: Composition and Size

December 6, 2023
palliative care

Understanding Palliative Care: Explained in Full

December 6, 2023
top 5 mistakes after knee replacement

Steer Clear of the Top 5 Mistakes After Knee Replacement for a Successful Recovery

December 5, 2023
Subscribe To Our Newsletter
About Us
About Us

DiseaseFix is primarily known as an online publisher of disease-centric medical information related to human health and well-being. The information is published as disease modules accessible to users from across the world free of cost.

Email Us: contact@diseasefix.com

Useful Links
  • Write For Us (Submit Guest Post)
  • Submit Your Healthcare Organization Profile
  • Submit Press Release
  • Content Guidelines & Healthcare Marketing Opportunities
Tools & Calculators
  • Weight Loss Calculator
  • Diabetes Risk Calculator
Company
  • Disease Index
  • About Us
  • Our Team
  • Privacy Policy
  • Disclaimer
  • Contact Us
Facebook X (Twitter) YouTube
© 2023 Diseasefix. All rights reserved.

Type above and press Enter to search. Press Esc to cancel.