ADHD Medications and Their Side Effects

Sana Masroor   by Sana Masroor, M.S., Biochemistry    Last updated on March 4, 2020,

ADHD is a neuropsychiatric disorder which is characterized by excessive activity, difficulty in paying attention and acting without regard to consequences (impulsiveness). It can be seen during childhood or adulthood.

Symptoms of this disease may be noticed at an early age. The disease can be easily noticed when a situations associated with a child changes, like when they start going to school.


What Medications are Used for Treating ADHD?

Genetic factors and other conditions like brain injury, traumas etc are considered to be the potential factors for ADHD. ADHD influences those parts of our brain which help us with different executive functioning like planning for future, regulating emotions and controlling our impulses. 

Medications are given to ADHD sufferers to increase their ability to pay attention, manage their impulsiveness and hyperactivity. These medications sometimes can also be used for people who suffer from sleep attacks (narcolepsy), chronic fatigue and to boost antidepressant effects. 

Different types of medications generally used to treat ADHD patients are: Stimulants and Non-stimulants.


These are the most common medications used for treating ADHD. Stimulants will help improve symptoms for about 70% children with ADHD.

Stimulants work by increasing dopamine (a neurotransmitter associated with pleasure, motivation, attention and movement) levels in the brain. Stimulants are most commonly used for attention deficit disorder.

Three main stimulant medications along with their active ingredients used for ADHD are:

  • Methylphenidate (Ritalin, Concerta and Biphentin)
  • Dextroamphetamine (Dexedrine, Vyanse and Dexedrine spansule)
  • Mixed amphetamine salts (Adderall XR)

Stimulants for ADHD come in both shorter and longer acting forms. Short-acting stimulants do not last for a long duration, so they are taken 2-3 times a day. Long-acting stimulants last for about 8-12 hours, and are usually taken just once a day. 

Non-Stimulant Medications

In cases where stimulants do not work or cause intolerable side effects, non-stimulants might help. These medications may help in increasing attentiveness and controlling impulse. Non stimulant medications include Strattera (atypical antidepressants) and certain blood pressure medications. 


  • Strattera (generic name is atomoxetine) is the only non-stimulant medication which has been approved by the Food and Drug Administration (FDA) for ADHD treatment. Strattera increases the level of norepinephrine (a brain chemical released under stress conditions).
  • Strattera effects last for a long time such as for over 24 hours. These medicines are longer acting than the stimulant drugs. They have antidepressant properties too.
  • Strattera doesn’t seem to be as effective as the stimulant medications for treating hyperactivity in ADHD patients.

Are There Any Side Effects Associated With ADHD Medications?

Although right ADHD medications make the life much easier for children and adults who have attention deficit hyperactivity disorder, but ADHD medications can sometimes also make things worse leading to severe side effects such as:

  • Nausea
  • Headache
  • Insomnia
  • Blunted appetite

Some common side effects of stimulant medications and non-stimulant medications for ADHD are:

Side Effects of ADHD Stimulant Drugs

Potential side effects of stimulant drugs include:

  • Sleep problems
  • Anxiety, depression
  • Delayed growth
  • Increase blood pressure
  • Headaches and stomach aches
  • Tics (repetitive movement or unwanted sounds)
  • Moodiness and irritatibility

Serious side effects of stimulant drugs include heart attack, sudden death and stroke.

Side effects of non stimulant drugs

 Non stimulant drugs can also cause side effects, which include:

  • Nausea
  • Stomachaches
  • Drowsiness
  • Fatigue
  • Mood swings
  • Loss of appetite

Frequently Asked Questions

Studies have reported that combining two standard medications can lead to greater clinical improvements for children with attentive deficit hyperactivity disorder (ADHD) than either ADHD therapy alone. At present, studies have shown that the use of several ADHD medications results in significant reductions of ADHD symptoms. You should consult your doctor before trying any combination.

ADHD medication may improve the ability to concentrate, plan ahead, control impulses, and follow through with tasks. Medication cannot completely cure ADHD. It can relieve symptoms only when it's being taken, but once medication stops, ADHD symptoms come back. ADHD drugs may help some people more than others, which means they give variable effects on different people.

Stimulants are the medications of choice in treating ADHD. There are of two types that are most commonly used: amphetamine and methylphenidate. These are also called smart drugs.

  • Methylphenidate (Ritalin, Concerta and Biphentin)
  • Mixed amphetamine salts (Adderall XR)

Physical tests, like blood tests, X-ray imaging etc cannot diagnose attention-deficit hyperactivity disorder (ADHD). ADHD diagnosis begins with a clinical interview by professionals/psychiatrists to know the medical history of a patient. This can be supplemented with some neuropsychological tests, which offer greater insights into strengths and weakness, and help identify comorbid conditions.

Evidences suggests that ADHD is genetic that is passed down from parents to a child. It is found to pass down in at least some families. At least 1/3 of fathers who have ADHD disease in their young age have their children with the same disease.

Sana Masroor

Sana Masroor is a biochemist and has pursued her Master’s degree in biochemistry from Jamia Millia Islamia University, New Delhi.  She has worked as a Research Trainee in the Special Center for Molecular Medicine, Jawaharlal Nehru University, New Delhi.

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